John and Eliza’s fourth son Octavius Molecey Twigge Molecey had followed in his grandfather's footsteps and qualified as a surgeon in 1862. He took to the high seas bound for Australia as a ship's doctor. He was aboard Messer's Greens ship Agamemnon which had sailed from the East India docks in 1869.
Sadly he was to die at sea on 17 August 1869 of an aneurism of the aorta, aged just 25, and was buried in Melbourne cemetery. A table tomb carved in West Deeping of Stamford stone was sent to Australia by his "sorrowing mother, brothers and sisters" to mark his resting place.